Lynch-SCAN
Non-invasive strategies to assess uterine cancer in Lynch syndrome carriers
Lynch Syndrome Carriers’ Uterine Cancer Health Assessment: Sampling and DNA-based Detection
Study Summary
Lynch syndrome (LS) is an inherited condition that increases an individual’s risk of developing certain cancers. For individuals with a uterus, LS is associated with more than a tenfold increase in the risk of developing endometrial cancer compared to the general population.
To reduce this risk, a hysterectomy is often recommended as a preventive measure. Others may be offered yearly pelvic ultrasounds and endometrial biopsies to monitor for signs of cancer. However, these tests can be uncomfortable, difficult to schedule, and particularly inaccessible for those in rural areas. Their effectiveness is also uncertain, which contributes to low adherence over time.
This study evaluates non-invasive strategies to assess uterine cancer in Lynch syndrome carriers.
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STUDY INVOLVEMENT
- Filling out questionnaires
- Up to 3 rounds of at-home, vaginal self-swabs
HOW PARTICIPATION AFFECTS YOU
- If molecular features are identified, you may be directed to an endometrial biopsy
- You may benefit from early treatment if uterine cancer or pre-cancerous changes are identified
Eligibility
You are eligible if you:
- are a carrier of Lynch syndrome confirmed by genetic testing
- have an intact uterus (e.g. no hysterectomy)
- are aged 30 years or over
You are not eligible if you:
- have a history of endometrial cancer or endometrial hyperplasia
- have a history of pelvic radiation or endometrial ablation
- are pregnant
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Speak with the Research Team